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While the combination of hormone replacement therapy and GLP-1 based medications shows strong early promise, much of the current evidence focuses on short-term weight outcomes rather than long-term effects on cardiovascular health, cognitive function, and overall healthspan Future research will need to be more precise

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The Bottom Line on Safety For healthy women starting hormone therapy within 10 years of menopause, the benefits typically outweigh the riskswhether taking estrogen alone (if no uterus) or combined therapy (if uterus intact)